A targetable fluorescent probe for imaging of mitochondrial viscosity in living cells

Literature Information

Publication Date 2019-09-03
DOI 10.1039/C9AY01575B
Impact Factor 2.896
Authors

Lixuan Dai, Mingguang Ren, Zihong Li, Li Wang, Weiying Lin


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Abstract

A novel targetable fluorescent probe was developed that could image mitochondrial viscosity in living cells. As the viscosity changes, the fluorescence spectrum of the probe changes significantly with fluorescence signal increases at 575 nm. This probe has good cell membrane permeability as evidenced by confocal fluorescence imaging experiments. Moreover, this probe has been shown to have a high colocalization coefficient through colocalization experiments with MitoTracker Green, indicating that the probe can accurately locate mitochondria.

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Analytical Methods welcomes early applications of new analytical and bioanalytical methods and technology demonstrating the potential for societal impact. We require that methods and technology reported in the journal are sufficiently innovative, robust, accurate, and compared to other available methods for the intended application. Developments with interdisciplinary approaches are particularly welcome. Systems should be proven with suitably complex and analytically challenging samples. We encourage developments within, but not limited to, the following technologies and applications: global health, point-of-care and molecular diagnostics biosensors and bioengineering drug development and pharmaceutical analysis applied microfluidics and nanotechnology omics studies, such as proteomics, metabolomics or glycomics environmental, agricultural and food science neuroscience biochemical and clinical analysis forensic analysis industrial process and method development

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