A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection
Literature Information
Duo Lin, Jiahui Zhou, Yun Yu, Weiwei Chen, Pei-Hsuan Liao, Hao Huang, Kien Voon Kong
A fast SERS and colorimetric dual-modal assay for thiol detection was developed using an unsaturated triosmium carbonyl cluster, Os3(CO)10(μ-H)2, as a detection probe. The cluster undergoes a distinct color change in the presence of thiol and the SERS spectrum shows a shift in the CO stretching vibration, located in a silent region where there is no interference from biomolecules. Such assay offers high sensitivity with a detection limit up to 0.1 μM by SERS.
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