![tert-butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate structure](https://static.chemtradehub.com/structs/336/336191-16-3-bb55.webp "tert-butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate structure")
tert-butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate
CAS Number:
336191-16-3
Molecular Formula:
C20H30N2O2
Surface-enhanced spatially-offset Raman spectroscopy (SESORS) for detection of neurochemicals through the skull at physiologically relevant concentrations
Literature Information
Publication Date
2020-01-16
DOI
10.1039/C9AN01708A
Impact Factor
4.616
Authors
Amber S. Moody, Taylor D. Payne, Brian A. Barth, Bhavya Sharma
View Original
Abstract
Detection techniques for neurotransmitters that are rapid, label-free, and non-invasive are needed to move towards earlier diagnosis of neurological disease. Surface-enhanced Raman spectroscopy (SERS) allows for sensitive and selective detection of target analytes. The combination of SERS with spatially offset Raman spectroscopy (SORS) in a technique termed surface enhanced spatially offset Raman spectroscopy (SESORS) permits a sensitive and selective detection of neurotransmitters through the skull. Here, we present the SESORS detection of individual neurotransmitters and mixtures of neurotransmitters at physiologically relevant concentrations, while also establishing limits of detection.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
4-(Bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene
CAS Number:
800381-60-6
Molecular Formula:
C14H16BrF3
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