Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry
Literature Information
Publication Date
2019-10-07
DOI
10.1039/C9AN01463B
Impact Factor
4.616
Authors
Bruno Pagano, Nunzia Iaccarino, Anna Di Porzio, Antonio Randazzo, Jussara Amato
View Original
Abstract
G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deemed to be a promising therapeutic approach. Herein is reported a proof of principle study on the use of nano differential scanning fluorimetry for a rapid and accurate analysis of G4-stabilizing ligands, exploiting the fluorescence properties of a 2-aminopurine modified G4-forming oligonucleotide.
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