![6-Benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3(2H)-one structure](https://static.chemtradehub.com/structs/909/909187-64-0-f54f.webp "6-Benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3(2H)-one structure")
6-Benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3(2H)-one
CAS Number:
909187-64-0
Molecular Formula:
C13H15N3O
Analysis of genome-wide in cell free DNA methylation: progress and prospect
Literature Information
Publication Date
2019-08-22
DOI
10.1039/C9AN00935C
Impact Factor
4.616
Authors
Zhiyu Liu, Zexin Wang, Erteng Jia, Tinglan Ouyang, Min Pan, Jiafeng Lu, Qinyu Ge, Yunfei Bai
View Original
Abstract
DNA methylation is an important epigenetic marker that affects gene expression. Cell-free DNA methylation detection is a promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This review summarizes the existing literature and reviews on the detection methods based on next generation sequencing for DNA methylation. The review also discusses the feasibility of detecting cfDNA methylation and the latest progress.
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