Fluorescence polarization-based detection of cancer-related mutations using target-initiated rolling circle amplification
Literature Information
Publication Date
2019-06-18
DOI
10.1039/C9AN00429G
Impact Factor
4.616
Authors
Woo Young Kwon, Byung Seok Cha, Seokjoon Kim, Sung Hyun Hwang, Ji Min Kim, Kalishwaralal Kalimuthu, Hyun Gyu Park, Ki Soo Park
View Original
Abstract
We devised a new method to detect cancer-related mutations based on target-initiated rolling circle amplification in combination with fluorescence polarization. We then applied this method to identify the presence of KRAS G13D and G12D, two of the most frequent mutations found in colorectal cancer patients, demonstrating high sensitivity and specificity.
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