Exploring the potential of a urea derivative: an AIE-luminogen and its interaction with human serum albumin in aqueous medium
Literature Information
Publication Date
2019-02-22
DOI
10.1039/C9AN00102F
Impact Factor
4.616
Authors
Senjuti Halder, Soham Samanta, Gopal Das
View Original
Abstract
A urea derivative L1 exhibits Aggregation-Induced Emission (AIE) activity in an acetonitrile–water mixed solvent. The aggregation phenomenon has been corroborated by microscopy and light scattering studies. The ligand (L1) also displays a selective turn-on fluorescence response towards human serum albumin (HSA) in 100% aqueous medium over various other comparable proteins (even bovine serum albumin (BSA)) and enzymes. The weakly emissive probe L1 showed a substantial increase in emission intensity upon binding with HSA through electrostatic interactions. The good linear relationship between the fluorescence enhancement (I/I0 − 1) and the concentration of HSA provided the scope to attain an impressive detection limit as low as 5 μg mL−1. A drug displacement experiment and molecular docking study were employed to ascertain the likely protein (HSA)–ligand binding interactions.
Related Literature
A novel three-dimensional heterometallic compound: templated assembly of the unprecedented planar “Na⊂[Cu4]” metalloporphyrin-like subunits
Yan-Feng Yue, Bing-Wu Wang, En-Qing Gao, Chen-Jie Fang, Cheng He, Chun-Hua Yan
2007-02-21
Communication
DOI: 10.1039/B618296H
Transformation of nanoporous oxoselenoantimonates into Sb2O3—nanoribbons and nanorods
Dorota Sendor, Thomas Weirich, Ulrich Simon
2005-10-20
Communication
DOI: 10.1039/B509657J
Conformational control of HCl co-transporter: imidazole functionalised isophthalamidevs. 2,6-dicarboxamidopyridine
Philip A. Gale, Joachim Garric, Mark E. Light, Beth A. McNally, Bradley D. Smith
2007-04-04
Communication
DOI: 10.1039/B703259E
Coordination chemistry of the hexavacant tungstophosphate [H2P2W12O48]12−: synthesis and characterization of iron(iii) complexes derived from the unprecedented {P2W14O54} fragment
Béatrice Godin, Jacqueline Vaissermann, Patrick Herson, Laurent Ruhlmann, Michel Verdaguer, Pierre Gouzerh
2005-10-19
Communication
DOI: 10.1039/B510434C
Molecular BioSystems issue 5 contents pages - free access to ChemComm subscribers
Front/Back Matter
DOI: 10.1039/B705434N
A recipe for new organometallic polymers and oligomers? Synthesis and structure of an oligo- and a polymeric arrangement of P–S anions‡
Maryam Shafaei-Fallah, Weifeng Shi
2007-01-23
Communication
DOI: 10.1039/B617177J
Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Julien Genovino, Jong Ho Lim, Christian Moessner
2007-02-14
Communication
DOI: 10.1039/B700827A
A bimetallic N-heterocyclic carbene complex featuring a short Cr–Cr distance
Kevin A. Kreisel, Glenn P. A. Yap, Klaus H. Theopold
2007-02-16
Communication
DOI: 10.1039/B616685G
Novel synthetic strategies for the preparation of prostacyclin and prostaglandin analogues – off the beaten track
Neil A. Sheddan, Michael Czybowski, Johann Mulzer
2007-03-14
Feature Article
DOI: 10.1039/B617693N
Vacuum-ultraviolet ionization spectroscopy of the jet-cooled RNA-base uracil
Kyo-Won Choi, Joo-Hee Lee, Sang Kyu Kim
2005-11-17
Communication
DOI: 10.1039/B512465D
You might also like
Compound Q&A
What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?
When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...
16712-20-2Lithium chloride hyd...
Compound Q&A
Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?
4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...
690261-92-84-(4H-1,2,4-Triazol-...
Compound Q&A
How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?
Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...
16733-85-01,3-Thiazole-2-carbo...
Compound Q&A
What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?
5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...
934175-58-35-(Difluoromethyl)-2...
Compound Q&A
How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?
Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...
22288-79-5Methyl 3-acetamido-2...
Compound Q&A
What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?
4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...
34846-65-64-Isoquinolinecarbon...
Compound Q&A
How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?
Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...
877309-59-6Methyl 1H-1,2,3-tria...
Compound Q&A
What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?
6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...
1160791-13-86-Bromo[1,3]thiazolo...
Compound Q&A
Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?
(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...
23651-95-8(2S,3S)-2-Ammonio-3-...
Compound Q&A
What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?
7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....
1293987-84-47-bromo-3-methyl-3,4...
Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.