Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A

Literature Information

Publication Date 2007-02-14
DOI 10.1039/B700827A
Impact Factor 6.222
Authors

Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Julien Genovino, Jong Ho Lim, Christian Moessner


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Abstract

The optimisation of a synthetic strategy towards the ABC segment of the cytotoxic macrolide spirastrellolide A is reported, together with its application to the synthesis of two diastereomeric C1–C22 fragments for stereochemical correlation purposes with a putative spirastrellolide degradation product.

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