Transition-metal-free cleavage of C–C double bonds: a three-component reaction of aromatic alkenes with S8 and amides towards aryl thioamides‡
Literature Information
Publication Date
2018-10-05
DOI
10.1039/C8QO00835C
Impact Factor
5.281
Authors
Zhanghong Guo, Kai Xu, Shuangshuang Hui, Xiaofang Zhao, Yangjie Wu
View Original
Abstract
A convenient and novel transition-metal-free cleavage of unstrained C–C double bonds has been developed from a three-component reaction involving aromatic alkenes, S8 and amides, which selectively provides a variety of aryl thioamides in up to 96% yields. This strategy features a simple operation and wide substrate scope. Note that internal aromatic alkenes and/or inactive acetamides could be applicable to this protocol.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(S)-(1,4-Dioxan-2-yl)methyl 4-methylbenzenesulfonate
CAS Number:
917882-64-5
Molecular Formula:
C12H16O5S
![(1S)-1,5-Anhydro-2-O-alpha-L-arabinopyranosyl-1-[5-hydroxy-7-({6-O-[3-(4-hydroxy-3-methoxyphenyl)propanoyl]-beta-D-glucopyranosyl}oxy)-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl]-D-glucitol structure](https://static.chemtradehub.com/structs/225/2252345-81-4-bcff.webp "(1S)-1,5-Anhydro-2-O-alpha-L-arabinopyranosyl-1-[5-hydroxy-7-({6-O-[3-(4-hydroxy-3-methoxyphenyl)propanoyl]-beta-D-glucopyranosyl}oxy)-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl]-D-glucitol structure")
![Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester structure](https://static.chemtradehub.com/structs/140/1404053-62-8-9da4.webp "Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester structure")
Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester
CAS Number:
1404053-62-8
Molecular Formula:
C40H59FN4O4
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