Solvent-free N-iodosuccinimide-promoted synthesis of spiroimidazolines from alkenes and amidines under ball-milling conditions
Literature Information
Publication Date
2018-09-03
DOI
10.1039/C8QO00723C
Impact Factor
5.281
Authors
Hui Xu, Kuan Chen, Hong-Wei Liu
View Original
Abstract
A novel N-iodosuccinimide-promoted intermolecular cyclization between alkenes and amidines has been demonstrated under solvent-free ball-milling conditions, affording a variety of spiroimidazolines with remarkable functional group tolerance and good to excellent yields. The present protocol features short reaction time, mild reaction conditions, high atom economy and feasibility of large-scale synthesis, providing an efficient and environmentally friendly access to spiroimidazolines.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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CAS Number:
1352810-38-8
Molecular Formula:
C53H39O4P
![19-[Chloro(dideuterio)methyl]-19-deuterio-20,20-dideuteriooxyoctatriacontane-18,21-dione structure](https://static.chemtradehub.com/structs/124/1246818-85-8-6244.webp "19-[Chloro(dideuterio)methyl]-19-deuterio-20,20-dideuteriooxyoctatriacontane-18,21-dione structure")
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CAS Number:
1246818-85-8
Molecular Formula:
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