Chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature

Literature Information

Publication Date 2018-05-10
DOI 10.1039/C8OB00907D
Impact Factor 3.876
Authors

Yao Peng, Jian Lei, Renhua Qiu, Lingteng Peng, Chak-Tong Au, Shuang-Feng Yin


View Original

Abstract

A protocol for the chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder under an oxygen atmosphere is reported. This reaction proceeds efficiently to afford fully substituted unsymmetrical N-arylation phosphinamides at room temperature in excellent yields. Diverse unstable functional groups on the benzene ring of aryl boronic acids such as vinyl, formyl, acetyl, sulfonyl, acetylamino, cyano, nitro, and trifluoromethyl can be accommodated.

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Inside front cover

Cover

DOI: 10.1039/D0QO90036B

Contents list

Front/Back Matter

DOI: 10.1039/C9OB90024A

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Source Journal

Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
Self-citation Rate: 10.3%
Articles per Year: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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