4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine
CAS Number:
485799-04-0
Molecular Formula:
C15H23BN2O3
HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues
Literature Information
Publication Date
2020-03-10
DOI
10.1039/D0QO00081G
Impact Factor
5.281
Authors
Xiaoyu Bai, Bowei Yang, Hansen Chen, Jiangang Shen, Dan Yang
View Original
Abstract
In order to understand the production and functions of HOCl in biological systems, a sensitive and selective detection method is urgently needed, especially for HOCl visualization in living cells and tissues. Herein we report a highly sensitive and selective rhodol-based fluorescent probe HKOCl-4 for HOCl detection. HKOCl-4r and HKOCl-4m, which were designed for better cellular uptake and mitochondria-targeting, respectively, have been successfully applied in detecting endogenous HOCl in macrophages. Furthermore, HOCl production in ischemic rat brain tissues has been visualized with HKOCl-4r in a middle cerebral artery occlusion (MCAO) model. These probes would serve as powerful imaging tools for delving into the roles of HOCl in health and disease.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
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8.7%
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724
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