Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles
Literature Information
Li Yuan, Sheng-Ming Jiang, Zeng-Zeng Li, Yong Zhu, Jian Yu, Lan Li, Ming-Zhu Li, Shi Tang
A visible-light-induced cascade Meerwein addition/cyclization of alkenes involving C–F bond cleavage was developed. This method offers a rapid access to azaspirocyclic cyclohexadienones from N-benzylacrylamides via C–F bond cleavage applying H2O as an external oxygen source, allowing for the incorporation of various aromatic moieties originating from aryldiazonium salts.
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Organic & Biomolecular Chemistry

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