Synthesis of multi-substituted dihydrofurans via palladium-catalysed coupling between 2,3-alkadienols and pronucleophiles

Literature Information

Publication Date 2018-04-23
DOI 10.1039/C8CC02589D
Impact Factor 6.222
Authors

Hirokazu Tsukamoto, Kazuya Ito, Takayuki Doi


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Abstract

Multi-substituted dihydrofurans were obtained from a palladium-catalysed coupling reaction between 2,3-alkadienols and ketones bearing an electron-withdrawing group at the α-position. Methanol as a solvent was essential for the initial dehydrative substitution to suppress the competitive hydroalkylation of the diene moiety. The substitution would be followed by intramolecular hydroalkoxylation under the same catalysis.

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Contents list

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