Highly hindered 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazoles: a new tool for the aqueous 19F- and 18F-fluorination of biomolecule-based structures

Literature Information

Publication Date 2018-05-01
DOI 10.1039/C8CC01782D
Impact Factor 6.222
Authors

Marion Tisseraud, Jürgen Schulz, Delphine Vimont, Murielle Berlande, Philippe Fernandez, Philippe Hermange, Eric Fouquet


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Abstract

A new class of silicon-based fluoride acceptors with a C-linked heterocycle as the leaving group was synthesized in one step from commercial chemicals, and linked to biomolecules. The resulting conjugates were efficiently 19F-fluorinated in aqueous mixtures, and switching to 18F-labelling provided nucleoside- and peptide-based bioconjugates with excellent molar activities suitable for biological applications.

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