Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
Literature Information
Abbas H. K. Al Temimi, Roman Belle, Kiran Kumar, Peter Betlem, Bas J. G. E. Pieters, Robert S. Paton, Jasmin Mecinović
Histone Nε-lysine methylation is a widespread posttranslational modification that is specifically recognised by a diverse class of Nε-methyllysine binding reader proteins. Combined thermodynamic data, molecular dynamics simulations, and quantum chemical studies reveal that reader proteins efficiently bind trimethylornithine and trimethylhomolysine, the simplest Nε-trimethyllysine analogues that differ in the length of the side chain.
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