5-Amino-1-(2,4-difluorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile
CAS Number:
1020057-92-4
Molecular Formula:
C11H8F2N4
A DNA minimachine for selective and sensitive detection of DNA
Literature Information
Publication Date
2018-12-07
DOI
10.1039/C8AN02274G
Impact Factor
4.616
Authors
Tatiana A. Lyalina, Ekaterina A. Goncharova, Nadezhda Y. Prokofeva
View Original
Abstract
Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here, we designed a multifunctional DNA nano-construct, dubbed a ‘DNA minimachine’ (DMM), which (i) tightly binds complementary DNA; (ii) recognizes specific fragments with high selectivity and (iii) amplifies output signals. DMM1 detects lower concentrations of both single-stranded DNA and double-stranded DNA compared to a conventional probe. This study sets a direction towards the development of molecular machines for selective, sensitive and cost-efficient DNA analysis.
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