Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides
Literature Information
Publication Date
2017-02-27
DOI
10.1039/C7QO00049A
Impact Factor
5.281
Authors
Zhuang Xiong, Dongdong Liang, Shuang Luo
View Original
Abstract
An efficient synthesis of N-acyl enamine amides via palladium-catalyzed alkene C–H activation and isocyanide insertion has been developed. The reaction was realized with good regioselectivity through directing-group-assisted alkenyl C(sp2)–H bond carboxamidation under mild conditions. A facile pathway to β-amino amides was achieved via reduction of the synthesized N-acyl enamine amides.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
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CAS Number:
1369160-12-2
Molecular Formula:
C7H8N2O2
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