1-(3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)thymine
CAS Number:
97614-47-6
Molecular Formula:
C24H21FN2O7
Can strand displacement take place in DNA triplexes?
Literature Information
Publication Date
2017-12-21
DOI
10.1039/C7OB02871G
Impact Factor
3.876
Authors
Qian Li, Cheng Tian, Xiang Li, Chengde Mao
View Original
Abstract
This work studies strand displacement in the context of DNA triplexes. We observed that toehold-mediated strand displacement could proceed in DNA triplexes, but at a much slower rate than in DNA duplexes. In this study, strand displacement was studied with native polyacrylamide gel electrophoresis (PAGE) for two molecular systems. While both systems were involved in branch migration in a DNA triplex, the toehold forms either a duplex or a triplex. This study provides a new strategy for sequence-specific strand displacement and it is useful for the construction of dynamic DNA nanostructures and control of smart DNA nanodevices.
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
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4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
CAS Number:
1194032-23-9
Molecular Formula:
C11H17F2NO4
2-Amino-2-(4-(pyridin-2-YL)phenyl)acetic acid hydrochloride
CAS Number:
1135818-89-1
Molecular Formula:
C13H13ClN2O2
![Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]- structure](https://static.chemtradehub.com/structs/661/66116-82-3-863e.webp "Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]- structure")
Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]-
CAS Number:
66116-82-3
Molecular Formula:
C7H7ClN2OS
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