Inhibition of lysozyme's polymerization activity using a polymer structural mimic
Literature Information
Publication Date
2018-05-29
DOI
10.1039/C8PY00545A
Impact Factor
5.582
Authors
D. L. Morris, T. C. Leeper, C. J. Ziegler
View Original
Abstract
Hen egg white lysozyme (HEWL) is a green catalyst capable of polymerizing 2-ethynylpyridine. 1,3-di(2-pyridyl)propane (DPP) is a mimic of the polymer repeating unit, and its interaction with HEWL reveals structural insight into the mechanism of polymerization. These interactions were probed using NMR methods, including diffusion-ordered spectroscopy (DOSY) and saturation transfer difference (STD) measurements, and the structure of HEWL with DPP in the active site was elucidated by X-ray methods.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
![(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide structure](https://static.chemtradehub.com/structs/250/2505001-54-5-c1e9.webp "(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide structure")
(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide
CAS Number:
2505001-54-5
Molecular Formula:
C16H20ClN3O4S
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