![2-Methyl-2-propanyl 1,6-diazaspiro[3.4]octane-6-carboxylate structure](https://static.chemtradehub.com/structs/115/1158749-79-1-81ee.webp "2-Methyl-2-propanyl 1,6-diazaspiro[3.4]octane-6-carboxylate structure")
2-Methyl-2-propanyl 1,6-diazaspiro[3.4]octane-6-carboxylate
CAS Number:
1158749-79-1
Molecular Formula:
C11H20N2O2
Surface enhanced Raman scattering sensor for highly sensitive and selective detection of ochratoxin A
Literature Information
Publication Date
2017-11-22
DOI
10.1039/C7AN01730H
Impact Factor
4.616
Authors
Mohamed N. Triba
View Original
Abstract
The trace detection of toxic compounds in complex matrices is a major concern, in particular when it comes to mycotoxins in food. We developed a highly sensitive and specific SERS sensor for the detection of ochratoxin A using a simple rough gold film as a substrate. When adding the analyte, we observed spectral variations related to the interaction of the analyte with the specific aptamer used as a bioreceptor. Using a partial least squares regression method, our sensor is able to detect concentrations down to the picomolar range, which is much lower than the minimum legal concentration allowed in food products. Moreover, we demonstrate the accurate detection of the analyte in a wide concentration range from the picomolar up to the micromolar level. The detection was validated with negative detection tests using deoxynivalenol and bovine serum albumin.
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Source Journal
Analyst
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7.8
Self-citation Rate:
5.6%
Articles per Year:
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
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