Copper-catalyzed 8-amido chelation-induced regioselective C–H fluoroalkylation of quinolines

Literature Information

Publication Date 2016-08-12
DOI 10.1039/C6QO00369A
Impact Factor 5.281
Authors

Li-Kun Jin, Guo-Ping Lu


View Original

Abstract

An efficient and highly regioselective protocol for copper(II)-catalyzed remote C–H fluoroalkylation of 8-aminoquinoline amides with RfSO2Na (Rf = CF3, CF2H, C4F9, C5F11, and C6F13) is described. This reaction provides an effective strategy for the direct construction of fluorine-containing six-membered heteroaromatic core structures.

Related Literature

Inside front cover

Front/Back Matter

DOI: 10.1039/B908006F

2,3-Functionalization of furans, benzofurans and thiophenesvia magnesiation and sulfoxide–magnesium exchange

Laurin Melzig, Christian B. Rauhut, Paul Knochel

2009-05-20 Communication

DOI: 10.1039/B907330B

Monodisperse Pt and PtRu/C60 hybrid nanoparticles for fuel cell anode catalysts

Jae Ha Shim, Hongkyu Kang, Ki Min Nam, Hyunjoon Song, Joon T. Park

2009-07-15 Communication

DOI: 10.1039/B911068B

Inside front cover

Front/Back Matter

DOI: 10.1039/B911249A

Self-assembly of a hydrogen bonded framework from a gold phosphine complex with a pendant uracil group

Tracy D. Nixon, Lee D. Dingwall, Jason M. Lynam, Adrian C. Whitwood

2009-04-06 Communication

DOI: 10.1039/B821671A

Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments

Yin Ding, Changjing Chen, Rutian Li, Yong Hu, Xiqun Jiang

2009-03-27 Communication

DOI: 10.1039/B900751B

Metal–organic macrocycles, metal–organic polyhedra and metal–organic frameworks

M. Jaya Prakash, Myoung Soo Lah

2009-04-28 Feature Article

DOI: 10.1039/B902988E

Facile synthetic strategy for efficient and multi-color fluorescent BCNO nanocrystals

Song Ye, Jianrong Qiu

2009-05-29 Communication

DOI: 10.1039/B904567H

Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system

Renato Mortera, Juan Vivero-Escoto, Igor I. Slowing, Edoardo Garrone, Barbara Onida, Victor S.-Y. Lin

2009-05-07 Communication

DOI: 10.1039/B900559E

You might also like

Compound Q&A

How should waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane be handled?

Waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane (...

100751-65-3[(6-Bromo-2-naphthyl...
Compound Q&A

How is 7-Fluoro-4-isoquinolinecarboxylic acid (CAS: 1841081-40-0) typically synthesized?

7-Fluoro-4-isoquinolinecarboxylic acid can be synthesized via a multi-step proce...

1841081-40-07-Fluoro-4-isoquinol...
Compound Q&A

What are the physical and chemical properties of 2,3,5,6-Tetrabromothieno[3,2-b]thiophene (CAS: 124638-53-5)?

2,3,5,6-Tetrabromothieno[3,2-b]thiophene is a crystalline compound with a high m...

124638-53-52,3,5,6-Tetrabromoth...
Compound Q&A

Is 1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CAS: 1542705-92-9) safe?

1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indol...

1542705-92-91-[4-(Benzylamino)-7...
Compound Q&A

What is the market or research trend for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo- (CAS: 113942-30-6)?

The market for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3...

113942-30-6Imidazo[5,1-d]-1,2,3...
Compound Q&A

What is 3-(Triisopropylsilyl)propiolaldehyde (CAS: 163271-80-5)?

3-(Triisopropylsilyl)propiolaldehyde is a synthetic organic compound with the CA...

163271-80-53-(Triisopropylsilyl...
Compound Q&A

What regulatory guidelines apply to 6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1)?

6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1) is subject to various regu...

81721-87-16-Nitro-2H-1,4-benzo...
Compound Q&A

How should waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)acetic acid (CAS: 885272-91-3) be handled?

Waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piper...

885272-91-3(3-Fluorophenyl)(4-{...
Compound Q&A

What are the physical and chemical properties of N,N'-4,4'-Biphenyldiyldiisonicotinamide (CAS: 55119-40-9)?

N,N'-4,4'-Biphenyldiyldiisonicotinamide is a white crystalline solid with a mole...

55119-40-9N,N'-4,4'-Biphenyldi...
Compound Q&A

What industries use 6-Bromo-8-fluoro-2-quinazolinol (CAS: 1036756-15-6)?

6-Bromo-8-fluoro-2-quinazolinol is primarily used in the pharmaceutical industry...

1036756-15-66-Bromo-8-fluoro-2-q...

Source Journal

Organic Chemistry Frontiers

Organic Chemistry Frontiers
CiteScore: 7.8
Self-citation Rate: 8.7%
Articles per Year: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.