Copper-catalyzed 8-amido chelation-induced regioselective C–H fluoroalkylation of quinolines

Literature Information

Publication Date 2016-08-12
DOI 10.1039/C6QO00369A
Impact Factor 5.281
Authors

Li-Kun Jin, Guo-Ping Lu


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Abstract

An efficient and highly regioselective protocol for copper(II)-catalyzed remote C–H fluoroalkylation of 8-aminoquinoline amides with RfSO2Na (Rf = CF3, CF2H, C4F9, C5F11, and C6F13) is described. This reaction provides an effective strategy for the direct construction of fluorine-containing six-membered heteroaromatic core structures.

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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