Cobalt-catalyzed synthesis of quinolines from the redox-neutral annulation of anilides and alkynes
Literature Information
Publication Date
2016-03-17
DOI
10.1039/C6QO00059B
Impact Factor
5.281
Authors
Qiangqiang Yan, Zhengkai Chen, Zhanxiang Liu
View Original
Abstract
A new method of cobalt-catalyzed annulation of anilides and internal alkynes for the efficient synthesis of quinoline scaffolds was developed. The combination of cobalt catalyst with the Lewis acid Zn(OTf)2 ensured the success of the annulation to give the quinoline heterocycles in high efficiency. The transformation is supposed to undergo ortho C–H activation and nucleophilic addition of C–Co species toward the amides. Attractive features of this system include the use of a low cost cobalt catalyst, the easy-handling operation, and readily available substrates.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
1-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid
CAS Number:
1152949-12-6
Molecular Formula:
C10H6Cl2N2O2
![2-Methyl-2-propanyl {3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-oxetanyl}carbamate structure](https://static.chemtradehub.com/structs/127/1279090-25-3-1b84.webp "2-Methyl-2-propanyl {3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-oxetanyl}carbamate structure")
2-Methyl-2-propanyl {3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-oxetanyl}carbamate
CAS Number:
1279090-25-3
Molecular Formula:
C20H30BNO5
(S)-(9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride
CAS Number:
1217813-15-4
Molecular Formula:
C20H23ClN2O2
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