Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes
Literature Information
Publication Date
2016-03-18
DOI
10.1039/C6AN00273K
Impact Factor
4.616
Authors
V. Cengiz Özalp, Dilek Çam, Frank J. Hernandez, Luiza I. Hernandez, Thomas Schäfer
View Original
Abstract
A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 μM up to 2 mM.
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