Double carboxylation of o-alkynyl acetophenone with carbon dioxide
Literature Information
Publication Date
2015-12-07
DOI
10.1039/C5QO00374A
Impact Factor
5.281
Authors
Wen-Zhen Zhang, Ming-Wang Yang, Xu-Tong Yang, Ling-Long Shi, Hui-Bo Wang, Xiao-Bing Lu
View Original
Abstract
A copper-catalyzed double carboxylation of o-alkynyl acetophenone using carbon dioxide to afford 1(3H)-isobenzofuranylidene dicarboxylic esters in good yields is described. The reaction proceeds via a carboxylation/intramolecular cyclization/carboxylation sequence. Alkyl-substituted substrates show much higher double carboxylation product selectivities than aryl-substituted substrates.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![2-Bromodibenzo[b,d]furan structure](https://static.chemtradehub.com/structs/86-/86-76-0-1814.webp "2-Bromodibenzo[b,d]furan structure")
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