Self-assembly of plasma protein through disulfide bond breaking and its use as a nanocarrier for lipophilic drugs

Literature Information

Publication Date 2014-05-16
DOI 10.1039/C4PY00212A
Impact Factor 5.582
Authors

Shudong Wang, Guangming Gong, Hua Su, Wenya Liu, Zhen Wang, Li Li


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Abstract

A disulfide bond breaking strategy used to fabricate HSA nanoparticles with dithiothreitol as the reducing agent is presented. The hydrophobic interaction is a dominating factor in the assembly process. These nanoparticles are suitable lipophilic drug delivery systems, which have significant tumor-targeting capabilities.

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