Copper-mediated radical alkylarylation of unactivated alkenes with acetonitrile leading to fluorenes and pyrroloindoles
Literature Information
Publication Date
2015-12-17
DOI
10.1039/C5QO00329F
Impact Factor
5.281
Authors
Xue-Qiang Chu, Zhen-Hua Xing, Hua Meng, Xiao-Ping Xu, Shun-Jun Ji
View Original
Abstract
A Cu-mediated/catalyzed selective oxidative dual C–H bond cleavage of an arene and alkylnitrile or acetone is reported. This method provides a novel approach to highly functionalized fluorene and pyrroloindole derivatives, which are useful in pharmaceutical and photoelectronic areas. In this reaction, two new C(sp3)–C(sp3) and C(Ar)–C(sp3) bonds, a quaternary center and a five-membered ring are simultaneously formed.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
Tris(2-ethylhexyl) 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
CAS Number:
88122-99-0
Molecular Formula:
C48H66N6O6
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