Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2
Literature Information
Publication Date
2015-10-06
DOI
10.1039/C5QO00255A
Impact Factor
5.281
Authors
Lei Lu, Juan Ma
View Original
Abstract
A general and efficient method for the synthesis of quinazolinones via acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes in water has been accomplished. In the presence of [Cp*Ir(H2O)3][OTf]2, a variety of desirable products were obtained in high yields with high atom economy under environmentally benign conditions. Notably, this research will facilitate the progress of acceptorless dehydrogenative reactions in water catalyzed by water-soluble organometallic complexes.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![tert-Butyl 6-chloro-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate structure](https://static.chemtradehub.com/structs/101/1011482-37-3-88a5.webp "tert-Butyl 6-chloro-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate structure")
tert-Butyl 6-chloro-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
CAS Number:
1011482-37-3
Molecular Formula:
C18H22ClNO4
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