Combining Pd(π-allyl)Cp and PPh3 as a unique catalyst for efficient synthesis of alkyliodo indoles via C(sp3)–I reductive elimination
Literature Information
Publication Date
2015-07-14
DOI
10.1039/C5QO00197H
Impact Factor
5.281
Authors
Wei Hao, Han Wang, Patrick J. Walsh, Zhenfeng Xi
View Original
Abstract
The combination of Pd(π-allyl)Cp and PPh3 was found to generate an efficient catalyst for the formation of indole-containing alkyl iodides from ortho-amino iodobenzenes and both aromatic and aliphatic alkynes. A unique feature of this reaction is a palladium-promoted C(sp3)–I bond formation via reductive elimination. This catalytic process was found to be very sensitive to the size and equivalents of phosphine ligands and the nature of the base.
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Organic Chemistry Frontiers
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