Synthesis of α-enamino esters via Cu(ii)-promoted dehydrogenation of α-amino acid esters: application to the synthesis of polysubstituted pyrroles
Literature Information
Publication Date
2015-09-29
DOI
10.1039/C5QO00182J
Impact Factor
5.281
Authors
Nini Zhou, Zhongle Li, Zhixiang Xie
View Original
Abstract
α-Enamino esters were efficiently prepared directly from readily available α-amino acid esters using a Cu(II)-promoted dehydrogenation with broad functional group tolerance and good to excellent yields. Moreover, the first application of α-enamino esters for the synthesis of polysubstituted pyrroles was achieved using an oxidative coupling with alkynes under Cu(II)-promoted conditions via intermolecular carbometalation of the alkyne in high yields.
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Source Journal
Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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