4-(Dimethylaminomethyl)phenylacetic acid hydrochloride
CAS Number:
99985-52-1
Molecular Formula:
C11H16ClNO2
New developments of ketonitrones in organic synthesis
Literature Information
Publication Date
2015-11-02
DOI
10.1039/C5QO00122F
Impact Factor
5.281
Authors
Wei-Min Shi, Xiao-Pan Ma, Gui-Fa Su, Dong-Liang Mo
View Original
Abstract
Nitrone chemistry has been widely developed for a long time and many reviews have outlined its rich transformation chemistry. However, most of these reviews involve aldonitrones due to their easy preparation and high reactivity. In recent years, N-substituents α,β-unsaturated ketonitrones and N-vinyl nitrones have attracted much attention of synthetic chemists to develop novel methodologies for their preparation and transformation. Various properties and new transformations of these nitrones have been discovered and applied into the synthesis of important heterocycle scaffolds. This review describes some recent breakthroughs in the development of new transformation of these nitrones. These new reactions include novel strategies for preparation of N-substituents α,β-unsaturated ketonitrones or N-vinyl nitrones, new rearrangement of nitrones, and reaction of nitrones with dipolarophiles such as alkynes, allenes and isocyanates.
Recommended Journals
Related Literature
Olefination of aldehydes with alpha-halo redox-active esters
Zhengqiang Liu, Wenbo H. Liu
2023-12-14
Research Article
DOI: 10.1039/D3QO01805A
Visible light as a sole requirement for alkylation of α-C(sp3)–H of N-aryltetrahydroisoquinolines with alkylboronic acids
Feihu Cong, Wenjing Zhang, Gan Zhang, Jie Liu, Yicheng Zhang, Chao Zhou
2023-10-15
Paper
DOI: 10.1039/D3OB01154B
A simple method for N-arylation of secondary amides/amines through a NaH-initiated aryne generation strategy
Yuanrui Jiang, Wenjing Zhu, Jiawen Huang, Fan Luo, Xiaobei Chen, Chunhui Fang, Xin Chen, Shihui Liu, Yanwei Hu, Shilei Zhang
2023-10-03
Research Article
DOI: 10.1039/D3QO01109G
Water-soluble hexakis-imidazolium cages: synthesis and selective binding of sodium urate
Sheng-Yi Zhuang, Gang Wu, Jian-Da Sun, Jiangshan Zhang, Jiabin Xing, Yan Wu, Hui Wang, Zhan-Ting Li, Dan-Wei Zhang
2023-11-27
Research Article
DOI: 10.1039/D3QO01780J
Light promoted metal-free regio- and stereoselective isoperfluoropropylation of unactivated alkenes with an i-C3F7-iodine(iii) reagent
Yaxing Wu, Yunchen Jiang, Fei Wang, Bin Wang, Chao Chen
2023-11-24
Research Article
DOI: 10.1039/D3QO01804K
B(C6F5)3-catalyzed stepwise 1,5-hydride migration/cyclization: diastereoselective construction of carbocyclic β-amino acid derivatives
Zhiting Wang, Hongchi Liu, Tianxiao Jiang
2023-12-11
Research Article
DOI: 10.1039/D3QO01637D
Access to disulfides through ligand-controlled nickel-catalyzed dithiosulfonate and alkyl halides
Wang Chen, Xin-yu Liu, Yi-Fan Jiang, Weidong Rao, Shu-Su Shen, Zhao-Ying Yang, Shun-Yi Wang
2023-12-19
Research Article
DOI: 10.1039/D3QO01868G
Isatin-based spiro indolenine alkaloids from Isatis indigotica Fortune with anti-neuroinflammatory and acetylcholinesterase inhibitory effects
Ming Bai, Yu-Fei Xi, Si-Hui Mi, Pei-Yuan Yang, Li-Li Lou, Tian-Ming Lv, Xin Zhang, Guo-Dong Yao, Bin Lin, Shao-Jiang Song
2023-11-21
Research Article
DOI: 10.1039/D3QO01769A
Radical-triggered base-free 1,3-C → C migrations: chemodivergent synthesis of cyclic imines from N-allyl enamines
Baihui Zheng, Junsheng Zhi, Nan Wang, Dandan Zhang, Hisashi Shimakoshi, Yifei Li, Qun Liu, Ling Pan
2023-12-19
Research Article
DOI: 10.1039/D3QO01849K
You might also like
Compound Q&A
How should 2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) be stored?
2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) should be stored in ...
615-45-22-Methylbenzene-1,4-...
Compound Q&A
Is (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide (CAS: 132747-20-7) safe?
(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide is generally considered sa...
132747-20-7(1S,4S)-2,5-Diazabic...
Compound Q&A
What industries use (6-Chloropyridazin-3-YL)methanamine (CAS: 871826-15-2)?
(6-Chloropyridazin-3-YL)methanamine finds applications in the pharmaceutical ind...
871826-15-2(6-Chloropyridazin-3...
Compound Q&A
What are the main uses of 2-Fluoro-3-methylphenol (CAS: 77772-72-6)?
2-Fluoro-3-methylphenol is primarily used in the synthesis of pharmaceuticals, p...
77772-72-62-Fluoro-3-methylphe...
Compound Q&A
What precautions should be taken when handling 3-Methoxy-4-nitrobenzonitrile (CAS: 177476-75-4)?
When handling 3-Methoxy-4-nitrobenzonitrile, it is important to wear appropriate...
177476-75-43-Methoxy-4-nitroben...
Compound Q&A
What precautions should be taken when handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4)?
When handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4), it is ...
211949-57-4[1,3]Oxazolo[4,5-b]p...
Compound Q&A
What regulatory guidelines apply to 4-Ethynylbenzamide (CAS: 90347-86-7)?
4-Ethynylbenzamide (CAS: 90347-86-7) falls under various regulatory guidelines i...
90347-86-74-Ethynylbenzamide
Compound Q&A
What are the main uses of 3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone (CAS: 186822-57-1)?
3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone is primarily used as an intermediat...
186822-57-13-(2-Ethylphenyl)-2-...
Compound Q&A
What is (2-Fluoro-6-methoxyphenyl)acetic acid (CAS: 500912-19-6)?
(2-Fluoro-6-methoxyphenyl)acetic acid, also known as 4-fluoro-3-methoxybenzoic a...
500912-19-6(2-Fluoro-6-methoxyp...
Compound Q&A
What is the market or research trend for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9)?
Market trends for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9) indicat...
102196-18-92-[4-(Hydroxymethyl)...
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
1-(3-Fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid
CAS Number:
1292369-51-7
Molecular Formula:
C9H6FN3O2
![4-[(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione structure](https://static.chemtradehub.com/structs/209/2093416-31-8-3162.webp "4-[(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione structure")
4-[(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS Number:
2093416-31-8
Molecular Formula:
C21H28N4O7
N1,N1-Bis(4-aminophenyl)benzene-1,4-diamine trihydrochloride
CAS Number:
114254-48-7
Molecular Formula:
C18H21Cl3N4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.