Poly(2-ethyl-2-oxazoline)-block-polycarbonate block copolymers: from improved end-group control in poly(2-oxazoline)s to chain extension with aliphatic polycarbonate through a fully metal-free ring-opening polymerisation process
Literature Information
Publication Date
2016-01-13
DOI
10.1039/C5PY01913C
Impact Factor
5.582
Authors
Victor R. de la Rosa, Sarah Tempelaar, Philippe Dubois, Richard Hoogenboom, Laetitia Mespouille
View Original
Abstract
Block copolymer micelles hold great promise for developing next generation drug delivery vehicles to improve therapeutics. In this work, the biocompatibility of poly(2-alkyl-2-oxazoline)s (PAOx) was combined with the biodegradability and biocompatibility of aliphatic polycarbonates through the preparation of block copolymers. These well-defined blocks were prepared via cationic ring-opening polymerisation (CROP) of 2-oxazolines followed by the organocatalytic ring-opening polymerisation (ROP) of cyclic carbonate monomers. The improved synthesis of hydroxyl terminated poly(2-ethyl-2-oxazoline)s (PEtOx-OH) is reported allowing high end-group fidelity. These polymers were used as macroinitiators in the controlled ROP of various cyclic carbonate monomers (TMC and benzyl, allyl, propargyl, bromide and morpholino functional monomers) resulting in well-defined amphiphilic block copolymers.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
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Recommended Compounds
![5-Chloropyrrolo[2,1-f][1,2,4]triazin-4(3H)-one structure](https://static.chemtradehub.com/structs/888/888720-60-3-4f7c.webp "5-Chloropyrrolo[2,1-f][1,2,4]triazin-4(3H)-one structure")
4-(4-Chloro-2-methoxyphenyl)-3-fluorobenzoic acid
CAS Number:
1261970-23-3
Molecular Formula:
C14H10ClFO3
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