Rhodamine based pH-sensitive “intelligent” polymers as lysosome targeting probes and their imaging applications in vivo
Literature Information
Publication Date
2014-06-16
DOI
10.1039/C4PY00646A
Impact Factor
5.582
Authors
Kang-Kang Yu, Ji-Ting Hou, Jin Yang, Yong-Mei Xie, Xiao-Qi Yu
View Original
Abstract
Two rhodamine-based polymers (P-1 and P-2) were prepared via free radical polymerization, which could serve as lysosome targeting probes with prominent pH sensitivity. The polymers exhibited suitable water solubility and the content of rhodamine in them was determined through 1H NMR and ultraviolet-visible absorption spectroscopy. Both P-1 and P-2 have excellent selectivity, membrane permeability and low cytotoxicity. Confocal microscopy was used to investigate the intracellular distribution of lysosomes and visualize pH-responsive changes in the liver of zebrafish. Moreover, fluorescence imaging of nude mice of P-1 and P-2 displayed a chance for the visualization of cancerous tissue in vivo by sensing the tumor acidic microenvironments.
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Polymer Chemistry
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