N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinamine
CAS Number:
1032759-30-0
Molecular Formula:
C12H20BN3O2
An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization
Literature Information
Publication Date
2014-04-01
DOI
10.1039/C4PY00207E
Impact Factor
5.582
Authors
Kelly A. Gilmore
View Original
Abstract
Polyester nanosponges were prepared with varied degrees of crosslinking densities of ∼4%, ∼7% and ∼10% and an average nanoscopic size of 100 nm. The crosslinking density and the influence towards the release kinetics of paclitaxel, a BCS class IV drug, for individual particles and a mixture of particles with two different crosslinking densities are investigated in buffer and gastrointestinal fluid to show fully adjustable release rates suitable for intravenous and oral delivery.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
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