An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

Literature Information

Publication Date 2014-04-01
DOI 10.1039/C4PY00207E
Impact Factor 5.582
Authors

Kelly A. Gilmore


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Abstract

Polyester nanosponges were prepared with varied degrees of crosslinking densities of ∼4%, ∼7% and ∼10% and an average nanoscopic size of 100 nm. The crosslinking density and the influence towards the release kinetics of paclitaxel, a BCS class IV drug, for individual particles and a mixture of particles with two different crosslinking densities are investigated in buffer and gastrointestinal fluid to show fully adjustable release rates suitable for intravenous and oral delivery.

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Polymer Chemistry

Polymer Chemistry
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Self-citation Rate: 7.3%
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Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

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