Quantitative evaluation of the ability of ionic liquids to offset the cold-induced unfolding of proteins

Literature Information

Publication Date 2014-05-19
DOI 10.1039/C4CP01001A
Impact Factor 3.676
Authors

Awanish Kumar, Anjeeta Rani, Pannuru Venkatesu, Anil Kumar


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Abstract

Significant non-reversible two-state denaturation was observed for proteins such as myoglobin (Mb) and α-chymotrypsin (CT) with decreasing temperature in the presence of 1-butyl-3-methylimidazolium-based ([C4mim]+X−) ionic liquids (ILs) with various anions (X−). Interestingly, for the first time, ILs having acetate and bromide anions were proven to counteract the cold-induced unfolding of proteins.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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