Multicomponent decarboxylative allylations

Literature Information

Publication Date 2014-09-25
DOI 10.1039/C4CC07253G
Impact Factor 6.222
Authors

Yamuna Ariyarathna, Jon A. Tunge


View Original

Abstract

The reaction of Meldrum's acid, pyrrolide, and allyl carbonates allows a multicomponent decarboxylative coupling to form allylated acyl pyrroles. This strategy is made possible by the in situ formation of β-oxo carboxylates from Meldrum's acid. Subsequent decarboxylative enolate formation and electrophilic allylation complete the reaction. Addition of benzylidene malononitriles as good Michael acceptors allow a 4-component interceptive decarboxylative allylation.

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