Mild and metal-free oxy- and amino-fluorination for the synthesis of fluorinated heterocycles

Literature Information

Publication Date 2014-09-26
DOI 10.1039/C4CC05027D
Impact Factor 6.222
Authors

Dixit Parmar, Magnus Rueping


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Abstract

A mild intramolecular fluoro-cyclisation reaction of benzylic alcohols and amines has been developed. This strategy uses commercially available Selectfluor to trigger electrophilic cyclisations to afford fluorinated heterocycles containing 1,3-disubstitution. The dual role of the reagent as a fluorine source and a base is shown to be crucial for reactivity.

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