Radical telomerization of fluorinated alkenes with dialkyl hydrogenophosphonates

This review summarizes various surveys on the synthesis of fluoroalkyl phosphonate derivatives by radical telomerization of fluorinated olefins with dialkyl H-phosphonates. For the past fifty years, numerous authors have reported such reactions involving a wide range of fluorinated olefins. Each class of fluorinated olefins is discussed in a dedicated paragraph, along with the influence that different parameters may have on the telomerization reactions: the nature of the solvent, the initial molar ratio of the reactants, the effect of the alkyl chain length of the H-phosphonates, and the nature of the initiator. Special attention has been given to the reported NMR data related to the adducts resulting from such reactions. The work discussed here opens up opportunities for further investigations that could deepen the knowledge on fluorinated derivatives of phosphonic acid.