Catalyst- and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels–Alder reaction strategy

Literature Information

Publication Date 2014-01-02
DOI 10.1039/C3GC42389A
Impact Factor 10.182
Authors

Debajyoti Bhuyan, Rupam Sarma, Yuvaraj Dommaraju, Dipak Prajapati


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Abstract

A pot, atom and step economic (PASE) synthesis of tetrahydroquinazolines has been achieved via a microwave-assisted four-component catalyst- and solvent-free aza-Diels–Alder reaction strategy. The key step of the methodology is the in situ generation of both the diene and the dienophile and their subsequent reaction to give the desired product.

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