GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

Literature Information

Publication Date 2013-09-25
DOI 10.1039/C3GC41799A
Impact Factor 10.182
Authors

Xuecheng Liu, Xian Feng, Zhibin Huang, Daqing Shi


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Abstract

A concise and efficient one-pot synthesis of pyrrolyl coumarin derivatives via a four-component reaction of 4-hydroxycoumarin, arylglyoxal monohydrate, dialkyl but-2-ynedioate and amines under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purification methods.

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