Polysialic acid as a drug carrier: evaluation of a new polysialic acid–epirubicin conjugate and its comparison against established drug carriers
Literature Information
Francesca Greco, Inam Arif, Ruth Botting, Cristina Fante, Luigi Quintieri, Chiara Clementi, Oddone Schiavon, Gianfranco Pasut
This paper explores the potential of polysialic acid (PSA) as a carrier for low molecular weight anticancer drugs. A PSA–epirubicin (Epi) conjugate was synthesized and compared against Epi conjugates containing established carriers, namely: N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers, poly(ethylene glycol) (PEG) and polyglutamic acid (PGA). Biological assessments in the breast cancer cell line MCF-7 and in the anthracycline resistant MCF-7/DX showed that the PSA–Epi conjugate had the highest activity (40% and 30% cell death in the two cell lines at 1 μM Epi equiv., respectively). FACS studies confirmed internalization of all conjugates by cholesterol-dependent endocytosis. PSA–Epi showed release of Epi (40% at 5 h) when incubated with lysosome extracts. In vivo evaluation showed that all conjugates had a significantly longer half-life compared to free Epi. This study also allowed an investigation on the effect of the polymeric carrier on the biological activity of a conjugate, with the biodegradability of the carrier emerging as an important feature.
Related Literature
Zero-point vibrational corrections to isotropic hyperfine coupling constants in polyatomic molecules
Zilvinas Rinkevicius, Kenneth Ruud, Hans Ågren
DOI: 10.1039/C0CP01443E
Thermal and photochemical oxidation of self-assembled monolayers on alumina particles exposed to nitrogen dioxide
Jonathan D. Raff, János Szanyi, Barbara J. Finlayson-Pitts
DOI: 10.1039/C0CP01041C
Vibrations of a single adsorbed organic molecule: anharmonicity matters!
Y. Scribano, A. Tschetschetkin, N. Maurer, B. Koslowski, P. Ziemann
DOI: 10.1039/C0CP01289K
Deformation of liquid-filled calciumalginatecapsules in a spinning drop apparatus
Sabine Leick, Stefan Henning, Patrick Degen, Dieter Suter, Heinz Rehage
DOI: 10.1039/B921116K
Fast optical vapour sensing by Bloch surface waves on porous siliconmembranes
Francesco Michelotti, Beniamino Sciacca, Lorenzo Dominici, Marzia Quaglio, Emiliano Descrovi, Fabrizio Giorgis, Francesco Geobaldo
DOI: 10.1039/B914280K
Synergistic effect of crystal and electronic structures on the visible-light-driven photocatalytic performances of Bi2O3 polymorphs
Hefeng Cheng, Baibiao Huang, Jibao Lu, Zeyan Wang, Bing Xu, Xiaoyan Qin, Xiaoyang Zhang, Ying Dai
DOI: 10.1039/C0CP01189D
You might also like
What are the main uses of 4-Nitrophenyl phosphate disodium salt hexahydrate (CAS: 333338-18-4)?
4-Nitrophenyl phosphate disodium salt hexahydrate is primarily used as a substra...
What are the main uses of 2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic Acid (CAS: 1060816-01-4)?
2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic Acid (CAS: 1060816-01-4) is widely ...
How should 2-Fluoro-4-biphenylcarboxylic acid (CAS: 137045-30-8) be stored?
2-Fluoro-4-biphenylcarboxylic acid should be stored in a cool, dry place at room...
What industries use Prednisolone-21-Carboxylic Acid (CAS: 61549-70-0)?
Prednisolone-21-Carboxylic Acid is primarily used in the pharmaceutical industry...
How should 4-(Hydrazinomethyl)-1,2,3-benzenetriol (CAS: 3614-72-0) be stored?
4-(Hydrazinomethyl)-1,2,3-benzenetriol (CAS: 3614-72-0) should be stored in a co...
What industries use 4-Amino-1-methyl-1H-pyrazole-5-carboxylic acid hydrochloride (CAS: 92534-70-8)?
4-Amino-1-methyl-1H-pyrazole-5-carboxylic acid hydrochloride (CAS: 92534-70-8) i...
What regulatory guidelines apply to dehydropachymic acid (CAS: 77012-31-8)?
Dehydropachymic acid (CAS: 77012-31-8) is regulated by various agencies. It fall...
What is the market or research trend for 6-[(2,2-Dimethylpropanoyl)amino]nicotinic acid (CAS: 898561-66-5)?
The market and research trends for 6-[(2,2-Dimethylpropanoyl)amino]nicotinic aci...
How should 1,10-Phenanthroline-2,9-dicarbaldehyde (CAS: 57709-62-3) be stored?
1,10-Phenanthroline-2,9-dicarbaldehyde should be stored in a cool, dry place awa...
How is 5-Carbamoyl-11-oxo-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate (CAS: 113952-21-9) typically synthesized?
5-Carbamoyl-11-oxo-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate can be synt...
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.











![5-Bromo-1H-pyrrolo[2,3-b]pyridine structure 5-Bromo-1H-pyrrolo[2,3-b]pyridine structure](https://static.chemtradehub.com/structs/183/183208-35-7-2d72.webp)


