Synthesis and antibacterial characterization of gemini surfactant monomers and copolymers

Literature Information

Publication Date 2012-01-30
DOI 10.1039/C2PY00558A
Impact Factor 5.582
Authors

Yi Zhang, Mingming Ding, Lijuan Zhou, Hong Tan, Jiehua Li, Huining Xiao, Jianshu Li, James Snow


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Abstract

A series of novel quaternary ammonium gemini monomers with broad-spectrum antibacterial activities were synthesized with a facile method. The surface tensions at various concentrations of gemini monomers were measured. The antibacterial and antifungal activities of these gemini monomers were evaluated by quantifying the minimal inhibitory concentration (MIC). The results indicated that the quaternary ammonium gemini monomers showed lower surface tensions and good activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as fungi, compared with a commercially available n-dodecyl-trimethylammonium bromide (DTAB). These monomers could be easily copolymerized with N-(3-aminopropyl) methacrylamide hydrochloride (APMA) using free radical polymerization to develop novel antibacterial polymers.

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Polymer Chemistry

Polymer Chemistry
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