3,3'-(Piperazine-1,4-diyl)bis(2-hydroxypropane-1-sulfonic acid) Sodium Salt
CAS Number:
108321-08-0
Molecular Formula:
C20H41N4Na3O16S4
Synthesis of glycosylated peptides by NCA polymerization for recognition of human T-cells
Literature Information
Publication Date
2011-07-28
DOI
10.1039/C1PY00187F
Impact Factor
5.582
Authors
Thomas Stöhr, André-René Blaudszun, Ute Steinfeld, Gerhard Wenz
View Original
Abstract
Peracetylated sugars (glucose, mannose, galactose) were attached via a thiourea linker to the ε-amino group of α-BOC-lysine and α-Z-lysine. After transformation to the N-carboxyanhydride (NCA), the product was copolymerized with both PEGylated lysine-NCA and ε-TFA-lysine-NCA by both tertiary amine and nickel complex catalysts. The resulting statistical copolypeptides are water-soluble after global deprotection and show an α-helical secondary structure. Fluorescein isothiocyanate (FITC) was then coupled to the free ε-NH2 groups of the lysine repeating units. The galactosylated fluorescent peptides are specifically incorporated in human T lymphocytes at 37 °C, as shown by flow cytometry and fluorescence microscopy. Therefore they are potentially useful for selective staining of cells or targeted drug delivery.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
![trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl structure](https://static.chemtradehub.com/structs/133/133937-72-1-25ef.webp "trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl structure")
trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl
CAS Number:
133937-72-1
Molecular Formula:
C22H31F3O
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