A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil adduct with antioxidant and anticancer properties

Literature Information

Publication Date 2011-09-05
DOI 10.1039/C1CC13821A
Impact Factor 6.222
Authors

Dong-Wei Li, Fang-Fang Tian, Yu-Shu Ge, Xin-Liang Ding, Jia-Han Li, Zi-Qiang Xu, Mei-Fang Zhang, Xiao-Le Han, Ran Li, Feng-Lei Jiang


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Abstract

A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil (VE-5-FU) adduct with antioxidant and anticancer properties for antioxidant-based cancer chemoprevention was synthesized and utilized for selective drug release in the stomach.

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