High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity

Literature Information

Publication Date 2011-08-24
DOI 10.1039/C1CC13552J
Impact Factor 6.222
Authors

Sital M. Patel, Maria de la Fuente, Song Ke, Andreia M. R. Guimarães, Adeola O. Oliyide, Xiaoyun Ji, Paul Stapleton, Anne Osbourn, Yi Pan, Dianna J. Bowles, Benjamin G. Davis, Andreas Schatzlein, Min Yang


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Abstract

Glycosylated analogues of novobiocin, discovered using a broad library of enzymes, have 100-fold improved activity against breast, brain, pancreatic, lung and ovarian cancers and ablated associated off-target activity leading to an up to 2.7 × 104 fold increase in selectivity.

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