Patterning small-molecule biocapture surfaces: microcontact insertion printing vs.photolithography‡

Literature Information

Publication Date 2011-08-26
DOI 10.1039/C1CC13002A
Impact Factor 6.222
Authors

H. H. Cao, A. I. Guttentag, J. E. McManigle, A. L. Gibb, M. M. Martinez, R. M. Nezarati, J. M. Hinds, W.-S. Liao, A. M. Andrews


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Abstract

Chemical patterns prepared by self-assembly, combined with soft lithography or photolithography, are directly compared. Pattern fidelity can be controlled in both cases but patterning at the low densities necessary for small-molecule probe capture of large biomolecule targets is better accomplished using microcontact insertion printing (μCIP). Surfaces patterned by μCIP are used to capture biomolecule binding partners for the small molecules dopamine and biotin.

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