Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy‡
Literature Information
Xiaobo Mao, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibing Wang, Yanlian Yang, Chen Wang
The binding behaviour of labeling molecule copper phthalocyanine tetrasulfonate sodium (PcCu(SO3Na)4) on the assemblies of representative polyamino acids has been studied by using scanning tunneling microscopy (STM). By directly visualizing the adsorption and distribution of the labeling species on the peptide assemblies in STM images, one could obtain relative binding affinities of the labeling molecule with different amino acid residues.
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