Gold(i)-catalyzed synthesis of furans and pyrrolesviaalkyne hydration
Literature Information
Pierrick Nun, Stéphanie Dupuy, Albert Poater, Luigi Cavallo, Steven P. Nolan
Furans and pyrroles were prepared via the gold(I)-catalyzed alkyne hydration of diynes. The use of [Au(IPr)OH] as precatalyst in a silver-free protocol permits low catalyst loadings and in situ generation of the active cationic gold species. A detailed computational study confirmed the experimental results and supports the proposed mechanism.
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