In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid

Literature Information

Publication Date 2010-01-22
DOI 10.1039/B923855G
Impact Factor 3.676
Authors

Katharina Bica, Christiaan Rijksen, Mark Nieuwenhuyzen


View Original

Abstract

We present an ionic liquid (IL) approach towards a dual functional liquid salt form of aspirin using different pharmaceutically active cations composed of antibacterials, analgesics, local anesthetics, and antiarrhythmic drugs in combination with acetylsalicylic acid or its metabolite salicylic acid and discuss stability of these ILs in comparison to solid salts. Several low-melting or liquid salts of salicylic acid with dual functionality and promising properties were isolated and characterized; however, although such ILs with aspirin could be prepared, they suffer from limited stability and slowly decompose into the corresponding salicylate ILs when exposed to moisture.

Related Literature

Csp3–F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions

Ainara Nova, Gregori Ujaque, Pilar González-Duarte, Agustí Lledós

2008-04-29 Communication

DOI: 10.1039/B801889H

Polymer-supported proline-decorated dendrons: dendritic effect in asymmetric aldol reaction

Tzofit Kehat, Moshe Portnoy

2007-06-05 Communication

DOI: 10.1039/B703016A

A multi-stage growth model leading to high-yield production of carbon nanotubes

Yajun Tian, Huaixin Yang, Shuanglin Zhan, Yunfa Chen

2008-05-16 Communication

DOI: 10.1039/B801966E

Electronic communication in “chain-like” trimetallic ruthenium complexes with two C7 carbon-rich conjugated bridges

Céline Olivier, Sylvie Choua, Philippe Turek, Daniel Touchard, Stéphane Rigaut

2007-05-17 Communication

DOI: 10.1039/B704241H

Synthesis and supramolecular assembly of clicked anionic dendritic polymers into polyion complex micelles‡

Ana Sousa-Herves, Eduardo Fernandez-Megia, Ricardo Riguera

2008-05-12 Communication

DOI: 10.1039/B805208E

Substrate mediated reduction of copper-amyloid-β complex in Alzheimer’s disease

Victor A. Streltsov, Joseph N. Varghese

2008-05-14 Communication

DOI: 10.1039/B803911A

A simple strategy for quantum dot assisted selective detection of cadmium ions

Subhash Banerjee, Soumitra Kar

2008-04-22 Communication

DOI: 10.1039/B803166E

Stereocontrolled synthesis of carbocyclesvia four successive pericyclic reactions

Roxanne Clément, Christiane M. Grisé, Louis Barriault

2008-06-06 Communication

DOI: 10.1039/B803898H

Fluorination reactions in microreactors

Tomas Gustafsson, Ryan Gilmour, Peter H. Seeberger

2008-04-29 Communication

DOI: 10.1039/B803695K

Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex

Masao Morita, Yasushi Obora, Yasutaka Ishii

2007-04-30 Communication

DOI: 10.1039/B702293J

You might also like

Compound Q&A

Are there alternatives to 1-(4-Chlorophenyl)-N-hydroxymethanimine (CAS: 3848-36-0) in synthesis?

When considering alternatives to 1-(4-Chlorophenyl)-N-hydroxymethanimine (CAS: 3...

3848-36-01-(4-Chlorophenyl)-N...
Compound Q&A

How is 3-(4-Bromophenyl)-5-(2-fluorophenyl)-1,2,4-oxadiazole (CAS: 419553-16-5) typically synthesized?

3-(4-Bromophenyl)-5-(2-fluorophenyl)-1,2,4-oxadiazole is synthesized through a m...

419553-16-53-(4-Bromophenyl)-5-...
Compound Q&A

How is 5-Chloro-2-(4-chlorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]pyrimidine (CAS: 1639220-19-1) typically synthesized?

5-Chloro-2-(4-chlorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]pyrimidine (CAS...

1639220-19-15-Chloro-2-(4-chloro...
Compound Q&A

What industries use 2-Chloro-4-(difluoromethoxy)pyridine (CAS: 1206978-15-5)?

2-Chloro-4-(difluoromethoxy)pyridine is used in the pharmaceutical industry for ...

1206978-15-52-Chloro-4-(difluoro...
Compound Q&A

What regulatory guidelines apply to 3-Chloro-6-methylpyridazine (CAS: 1121-79-5)?

3-Chloro-6-methylpyridazine (CAS: 1121-79-5) is classified under the Globally Ha...

1121-79-53-Chloro-6-methylpyr...
Compound Q&A

Are there alternatives to Methyl 4,5-dimethyl-2-nitrobenzoate in synthesis?

Several alternatives can be used in the synthesis of Methyl 4,5-dimethyl-2-nitro...

90922-74-0Methyl 4,5-dimethyl-...
Compound Q&A

Are there alternatives to (2E,2'E)-3,3'-(1,4-Phenylene)bisacrylaldehyde in synthesis?

Alternatives to (2E,2'E)-3,3'-(1,4-Phenylene)bisacrylaldehyde include other acry...

63405-68-5(2E,2'E)-3,3'-(1,4-P...
Compound Q&A

What is 3-Amino-5-chloropyridin-2-ol hydrochloride (CAS: 1261906-29-9)?

3-Amino-5-chloropyridin-2-ol hydrochloride is an organic compound with the CAS n...

1261906-29-93-Amino-5-chloropyri...
Compound Q&A

What precautions should be taken when handling 6,7-Difluoro-2,3-dihydro-4H-chromen-4-one (CAS: 1092349-93-3)?

When handling 6,7-Difluoro-2,3-dihydro-4H-chromen-4-one, it is essential to wear...

1092349-93-36,7-Difluoro-2,3-dih...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.