Substrate mediated reduction of copper-amyloid-β complex in Alzheimer’s disease

Literature Information

Publication Date 2008-05-14
DOI 10.1039/B803911A
Impact Factor 6.222
Authors

Victor A. Streltsov, Joseph N. Varghese


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Abstract

X-Ray absorption near-edge spectroscopy (XANES) has been used to probe the substrate mediated reduction of Cu2+ in Aβ-Cu2+ complexes by ascorbate and the neurotoxin 6-hydroxydopamine (6-OHDA), however dopamine and, in particular, cholesterol are incapable of reducing soluble monomeric Aβ-Cu2+ complexes.

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