Substrate mediated reduction of copper-amyloid-β complex in Alzheimer’s disease
Literature Information
Victor A. Streltsov, Joseph N. Varghese
X-Ray absorption near-edge spectroscopy (XANES) has been used to probe the substrate mediated reduction of Cu2+ in Aβ-Cu2+ complexes by ascorbate and the neurotoxin 6-hydroxydopamine (6-OHDA), however dopamine and, in particular, cholesterol are incapable of reducing soluble monomeric Aβ-Cu2+ complexes.
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![2-{[(1R,2S)-2-Aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}-5-pyrimidinecarboxamide structure 2-{[(1R,2S)-2-Aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}-5-pyrimidinecarboxamide structure](https://static.chemtradehub.com/structs/137/1370261-96-3-40df.webp)